Equipment and storage facilities

Particularly our offer in the field of special analytics and troubleshooting requires an extensive equipment park with state-of-the-art measuring instruments. We would like to invite you on a virtual tour of our laboratory and present you a part of our equipment in the following. Of course, you are also welcome to get a "live impression" of our laboratory and storage facilities directly on site during an audit or a customer visit.

EQUIPMENT

INTERLABOR has the claim to carry out a wide range of analyses for you competently and with high quality. For this reason, we regularly invest in state-of-the-art equipment. Below you will find an extract from our equipment park with the most important key figures.

HPLC/UPLC equipment park (Thermo/Agilent) with the following detectors

  • Variable Wavelength Detector (VWD)

    Variable Wavelength Detector (VWD) for the detection of analytes that absorb in the ultraviolet or visible wavelength range. The detector is therefore well suited for the detection of aromatic or unsaturated compounds. Analytes with chromophoric groups can also be detected. It allows the determination of a large number of substances (APIs, excipients) over a large spectral working range.

  • Diodenarray-Detector (DAD)

    Diodenarray-Detector (DAD) also enables the detection of analytes that absorb in the ultraviolet and visible wavelength range. In contrast to VWD, different wavelengths can be determined simultaneously. The great advantage of the detector is the direct recording of UV spectra of the signal, which allows a better identification of the analyte.

  • Fluorescence Detector (FLD)

    Fluorescence Detector (FLD) for the detection of fluorescent analytes or substances that can be converted into such analytes by derivatisation. The detector has a high selectivity and is well suited for analytes with aromatic systems or fluorophores.

  • Evaporative Light Scattering Detector (ELSD)

    Evaporative Light Scattering Detector (ELSD) is suitable for the detection of low volatile analytes containing no chromophores (UV/VIS inactive). The signal obtained is mainly determined by the molecular mass of the analyte and not by functional groups. The detector is well suited for gradient systems. Since the mobile phase must be volatile, the use of buffers and additives is limited.

  • Refractive Index Detector (RID)

    Refractive Index Detector (RID) is a universal detector that is often used to complement UV detectors as compounds with little or no UV activity (e.g. sugars, alcohols, amino acids) can also be determined. The detection is based on the different refractive index of the pure mobile phase and the dissolved analyte.

  • Charged Aerosol Detector (CAD)

    Charged Aerosol Detector (CAD) like ELSD systems, is suitable for the detection of non-volatile analytes that do not contain chromophores. Furthermore, CAD systems have a larger linear range than ELSD.

  • Electrochemical Detector (ECD)

    Electrochemical Detector (ECD) enables the determination of electrochemically active analytes with high sensitivity and selectivity. The detector is well suited for the detection of oxidizable or reducible analytes such as sugars or alcohols.
     

Various HPLC/UPLC instruments (Thermo & Waters)

  • Ultra Performance Liquid Chromatographie (UPLC)

    In contrast to HPLC, Ultra Performance Liquid Chromatography (UPLC) uses particle sizes below 2 µm and shorter columns in the range of 30 to 50 mm. The advantages of UPLC are high sensitivity and resolution and short analysis times. The basic requirement for the use of UPLC are LC systems, which allow the handling of the high pressures of 800 bar and more due to the small particle sizes.

HRMS-ToF (Waters Synapt G2)

  • Mass spectrometer

    Our high-resolution mass spectrometer has a high mass accuracy and resolution. The mass deviation is below 0.2 mDa. It is ideally suited for the calculation of the elemental composition of unknown signals and thus enables structural proposals for unknown impurities or degradation products.

Sciex Triple Quad 6500+
(Sciex Applied Biosystems)

  • Sciex Triple Quad 6500+ (Sciex Applied Biosystems)

    Our Sciex Triple Quad 6500+ allows screening of up to 250 analytes. APCI and ESI are available as ionisation methods in positive and negative mode.

GC equipment pool (Agilent) with the following detectors

  • Flame Ionisation Detector (FID)

    Flame Ionisation Detector (FID) is a universal detector with high sensitivity and wide linear range, which is particularly suitable for hydrocarbons.

  • Micro-Electron Capture Detector (µ-ECD)

    Micro-Electron Capture Detector (µ-ECD) is used for the determination of analytes with electronegative functional groups. Thus, the very selective detection of nitrated, halogenated or sulphur-containing analytes, for example chlorinated pesticides is possible.

  • Nitrogen–Phosphorus Detector (NPD)

    Nitrogen–Phosphorus Detector (NPD) is suitable for the determination of analytes containing nitrogen and phosphorus and is often used in trace analysis due to its high selectivity and sensitivity.

  • Flame Photometric Detector (FPD)

    Flame Photometric Detector (FDP) is a detector with high sensitivity for phosphorous and sulphur containing analytes.

  • Mass Spectrometric Detector (MSD)

    Mass Spectrometric Detector (MSD) is a universal detector with very high sensitivity. Depending on the compound, the detection limits are in the range from pico- to nanogram.

6890A GC-MS with 5973N MSD (Agilent)
with the following feeding systems

  • Thermal Desorption Unit (TDU)

    Thermal Desorption Unit (TDU) is a delivery system for small sample quantities based on thermal mobilization of components with subsequent cryofocusing. TDU enables the thermal desorption (extraction) of adsorbent tubes for gases, twisters for liquids or even solid samples.

  • Headspace (HS)

    Headspace (HS) is a vapor space analysis of mostly liquid or dissolved samples (static).

  • Dynamic Headspace (DHS)

    Dynamic Headspace (DHS) is a vapour space analysis (dynamic) with collection of the volatile components for concentration.

  • Twister/Solid Phase Microextraction (SPME)

    Twister/Solid Phase Microextraction (SPME) techniques enable targeted extraction of substances or substance classes from various samples.

  • Cold Feed System (CFS)

    Cold Feed System (CFS) enables the sample to be injected onto the chromatographic column through a temperature-controlled, septum-free injection system from -120°C to 350°C. It allows focusing at the head of the column and controlled start of the chromatography.

  • Stir Bar Sorptive Extraction (SBSE)

    Stir Bar Sorptive Extraction (SBSE) Twister and SPME are used in the extraction of liquids. With alternating coating of the SPME capillary or the Twister wall, compounds with different polarities can be adsorbed. Twisters can also be used as passive collectors.

7000C Triple Quad (Agilent) with 7890B GC

  • Triple Quad

    Our Triple Quad enables in Multiple Reaction Monitoring (MRM) mode the very sensitive and selective detection of over 250 compounds.

Energy Dispersive X-Ray Fluorescence
(ED-XRF Rigaku)

  • ED-XRF

    Our ED-XRF enables a qualitative statement on the elemental composition of a material to be made within a very short time. The spectroscopic method is also non-destructive and thus suitable for the analysis of entire objects such as building materials.

Inductively Coupled Plasma Mass Spectrometry (ICP-MS Agilent 7700)

  • ICP-MS

    Our ICP-MS allows the determination of up to 70 elements within one sequence. ICP-MS is ideally suited for the rapid validation of limits in the low ppm to ppt range and is frequently used in trace and residue analysis.

Cold Vapour Atomic Fluorescence
Spectroscopy (CV/AFS Analytik Jena)

  • CV/AFS

    Our CV/AFS enables the quantification of mercury with very low detection limits in the range of ng/L

Atomic Absorption Spectroscopy
(AAS Analytik Jena)

  • AAS

    Our AAS is a flexible tandem instrument with two sample chambers for flame and graphite furnace techniques with Zeeman background correction. It enables the determination of the content of individual elements with good precision and accuracy, for example according to pharmacopoeia monographs or customer methods.

STABILITY STUDIES

Stability studies including photostabilities according to ICH guidelines or customer specifications can be carried out. With a volume of over 200 m3 your product will also find a place with us.

STABILITY STUDIES

Overview of storage conditions and facilities for stability studies:

  • -20 °C (freezing room 10000 L) & 5 °C (cold room 20000 L)
  • 25 °C/60% rH (climatic chambers 2 x 35000 L)
  • 30 °C/65% rh (climatic chamber 35000 L) & 30 °C/75% rh (climatic chamber 20000 L)
  • 40 °C/75% rh (climatic chamber 10000 L)
  • Variable 0 to +60 °C (climatic cabinets 2 x 1000 L) & -20 to +60 °C (1 x 1000 L)

SAFETY CONCEPT

We have a comprehensive safety concept for our storage facilities:

  • Ventilated and explosion-proof rooms equipped with gas sensors
  • GMP-compliant qualification and archiving of the T/rF data for 10 years
  • Online monitoring of temperature and relative humidity with Thermoguard
  • Alarm via e-mail and SMS in case of limit value violations or power failure
  • Use of two humidity probes with different sensors for drift detection

Storage facilities with online monitoring

    Storage facilities with online monitoring

      Cold storage facilities

        Redundant determination of the relative
        humidity with two different sensors

          Gas sensor for the safe storage of
          cans containing propellant gases

            Mobile climatic chambers for customer-specific
            conditions, for example freeze-thaw cycles

              suntester for photostabilities

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